Innovative silicon nanochip can reprogram biological tissue in a living body – sciencedaily


A silicon device that can turn skin tissue into blood vessels and nerve cells has moved from prototype to standardized manufacturing, which means it can now be manufactured in a consistent and reproducible manner. As stated in Natural protocols, this work, developed by researchers at Indiana University School of Medicine, brings the device closer to potential use as a treatment for people with various health conditions.

The technology, called tissue nanotransfection, is a non-invasive nanochip device that can reprogram tissue function by applying a harmless electrical spark to deliver specific genes in a fraction of a second. In laboratory studies, the device successfully converted skin tissue into blood vessels to repair a badly injured leg. The technology is currently used to reprogram tissues for different types of therapies, such as repairing brain damage caused by stroke or preventing and reversing nerve damage caused by diabetes.

“This report on how to produce exactly these tissue nanotransfection chips will allow other researchers to participate in this new development in regenerative medicine,” said Chandan Sen, director of the Indiana Center for Regenerative Medicine and Engineering, vice associate president for research and professor emeritus. at IU School of Medicine.

Sen also heads the Regenerative Medicine and Engineering Science Pillar of the IU Precision Health Initiative and is the lead author of the new publication.

“This tiny silicon chip enables nanotechnology that can change the function of living parts of the body,” he said. “For example, if a person’s blood vessels have been damaged due to a traffic accident and they need a blood supply, we can no longer rely on the pre-existing blood vessel because it is crushed, but we can convert the skin tissue into blood vessels and save the limb at risk. “

In the Nature Protocols report, the researchers published technical details of how the chip was made.

Sen said this manufacturing information will lead to further development of the chip in the hope that it will one day be used clinically in many settings around the world.

“It’s about the engineering and manufacturing of the chip,” he said. “The process of nanofabrication of the chip typically takes five to six days and, with the help of this report, can be performed by anyone skilled in the art.”

Sen said he hopes to get FDA approval for the chip within a year. Once it receives FDA approval, the device could be used for clinical research in humans, including patients in hospitals, health centers and emergency rooms, as well as in other emergencies by first responders or the military.

Other study authors include Yi Xuan, Subhadip Ghatak, Andrew Clark, Zhigang Li, Savita Khanna, Dongmin Pak, Mangilal Agarwal, and Sashwati Roy, all from IU, and Peter Duda from the University of Chicago.

This research is funded by the National Institutes of Health.

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Material provided by Indiana University. Note: Content can be changed for style and length.

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